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The Genetics of FVL, by Jennifer Rosenberg

+= one copy of the mutated gene
-= one copy of the normal gene
--=normal
+-=heterozygous for the mutated gene
++=homozygous for the mutated gene

 

If both parents are normal, each parent contributes one normal gene and all children (gray boxes) are normal (don't have the genetic condition):



Parents

-

-

-

--

--

-

--

--

 

If one parent is heterozygous(+-), and the other is normal(--), then the heterozygous parent passes on either a mutated gene or a normal gene, and the normal parent passes on a normal gene. There is a 50% chance of any offspring being heterozygous, and a 50% chance of them being normal.



P

+

-

-

+-

--

-

+-

--

 

If both parents are heterozygous(+-), each parent will pass along either a normal or a mutated gene. 25% chance of offspring being homozygous (++), 50% chance of offspring being heterozygous (+-) and 25% chance of any offspring being normal.



P

+

-

+

++

-+

-

+-

--

 

If one parent is homozygous(++) and the other is normal(--), all offspring will be heterozygous (+-).



P

+

+

-

+-

+-

-

+-

+-

 

If one parent is homozygous(++) and the other is heterozygous(+-), 50% chance of offspring being homozygous(++) and 50% chance of offspring being heterozygous(+-).



P

+

+

+

++

++

-

+-

+-

 

If both parents are homozygous (++) all children will be homozygous (++)



P

+

+

+

++

++

+

++

++



Contributions in design from Jennifer Rosenberg.


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