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Ask Dr. Stephan Moll
These questions have been submitted by folks on the mailing list and answered by Dr. Moll, Director of the Thrombophilia Program at the Carolina Cardiovascular Biology Center, Department of Medicine, Division of Hematology-Oncology, UNC Chapel Hill (North Carolina, USA). Why am I doing this?
16. Pregnancy loss - and thrombophilias
Last Updated: 2/15/2004
Q: "My sisters have both been diagnosed with factor V Leiden hetero. One sister had one miscarriage
and two stillbirths (one at 7 mo. and the other at 6 mo.). The other sister had one miscarriage and three normal pregnancies. What could be the
difference between my two sisters to have such different outcomes in their pregnancies?"
A: Pregnancy loss (as well as thrombosis) is often a multifactorial problem, that is: several risk factors come together to cause the pregnancy loss (or the thrombosis). Factor V Leiden is only one of the risk factors. Likely, your one sister has more risk factors than the other.
There are many reasons for pregnancy loss, and reasons differ, depending on whether it is a 1st, 2nd, or 3rd trimester loss. Details of the pregnancy
loss are very important in the attempt to understand the reason for the pregnancy loss and to decide, whether thrombophilia work-up should be done,
and heparin (such as Lovenox®, Fragmin®, or others) and possibly additional aspirin recommended for future pregnancies.
The information contained on the this web site is provided for your general information only. I am not a doctor and I do not give medical advice or engage in the practice of medicine. I do not recommend any particular treatment/trial for individuals, and in all cases recommend that you consult your physician or local treatment center before pursuing any course of treatment. It is up to you, as a consumer to find out if these trials posted are something you want to participate in. I just post the information.